However, there is debate still going on out there amongst the other experts on whether it is best to take creatine pre-workout or post-workout. Well, for those who. Creatine is found in a lot of pre-workout supplements, but is that the best time to take it? Learn how timing and dosage can affect your results in the gym. According to the most relevant research, taking 5 grams creatine monohydrate both pre and post workout is the most effective way to utilize creatine for strength .